Spicy Cajun Chicken Alfredo

Featured in: Cozy Dinner Bowls

This dish features tender chicken breasts coated in Cajun seasoning, pan-seared to a golden finish, and served over fettuccine tossed in a creamy Alfredo sauce. The sauce is flavored with butter, garlic, heavy cream, Parmesan cheese, smoked paprika, and a pinch of chili flakes for extra warmth. A touch of reserved pasta water ensures a silky texture, while fresh parsley and extra Parmesan add brightness and depth. This combination balances smoky, spicy, and cheesy flavors for a satisfying meal perfect for those who enjoy a bold and creamy pasta experience.

Updated on Sat, 15 Nov 2025 14:32:00 GMT
Creamy Cajun Chicken Alfredo, a delectable pasta dish with perfectly seasoned chicken pieces. Save to Pinterest
Creamy Cajun Chicken Alfredo, a delectable pasta dish with perfectly seasoned chicken pieces. | lovelyserena.com

A bold creamy pasta dish featuring tender Cajun-spiced chicken tossed with fettuccine in a rich Alfredo sauce perfect for spice lovers.

This dish became a weeknight favorite in my house once I discovered how easy it is to whip up Cajun Alfredo at home. The perfect amount of spice and creaminess makes it one we always return to.

Ingredients

  • Boneless skinless chicken breasts: 2 large
  • Cajun seasoning: 2 tablespoons
  • Olive oil: 1 tablespoon
  • Fettuccine: 340 g (12 oz)
  • Unsalted butter: 2 tablespoons
  • Garlic (minced): 3 cloves
  • Heavy cream: 1 cup (240 ml)
  • Parmesan cheese (freshly grated): 1 cup (100 g)
  • Smoked paprika: 1/2 teaspoon
  • Chili flakes (optional): 1/2 teaspoon
  • Salt and black pepper: To taste
  • Chopped fresh parsley: 2 tablespoons
  • Extra grated Parmesan cheese: For garnish

Instructions

Cook Pasta:
Prepare fettuccine in salted boiling water until al dente. Reserve 1/2 cup pasta water drain and set aside.
Season Chicken:
Pat chicken breasts dry coat with Cajun seasoning.
Cook Chicken:
Heat olive oil in large skillet over medium-high heat. Add chicken cook 5 6 minutes per side until cooked and golden brown. Remove chicken rest 5 minutes then slice thinly.
Make Sauce:
In same skillet reduce heat to medium add butter. Sauté garlic for 1 minute until fragrant.
Finish Alfredo Sauce:
Stir in heavy cream smoked paprika chili flakes. Simmer then whisk Parmesan until melted and smooth. Season with salt and pepper.
Combine Pasta and Sauce:
Add fettuccine to sauce toss to coat. Add reserved pasta water as needed for silkier texture.
Serve:
Top with sliced Cajun chicken garnish parsley and extra Parmesan. Serve immediately.
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It brings everyone to the table and the kids love swirling the creamy noodles while the grownups go for that extra hit of Cajun spice.

Required Tools

Large pot large skillet tongs chefs knife cutting board measuring cups and spoons

Allergen Information

Contains dairy gluten may contain allergens in Cajun seasoning always check labels for potential cross-contamination.

Nutritional Information

Calories: 610 Total Fat: 27 g Carbohydrates: 54 g Protein: 38 g per serving

A comforting bowl of Spicy Cajun Chicken Alfredo with vibrant parsley and grated Parmesan on top. Save to Pinterest
A comforting bowl of Spicy Cajun Chicken Alfredo with vibrant parsley and grated Parmesan on top. | lovelyserena.com

Serve immediately for best texture and flavor. This Cajun Alfredo makes any night a little more special.

Ask About This Recipe

How do I ensure the chicken remains tender?

Pat the chicken dry before seasoning with Cajun spices and cook it over medium-high heat until golden brown but still juicy. Let it rest before slicing to retain moisture.

Can I substitute the pasta type?

Yes, penne or linguine work well as alternatives to fettuccine and will hold the creamy sauce nicely.

What adds the smoky flavor in the sauce?

Smoked paprika contributes a subtle smoky undertone that complements the Cajun spices and creamy Parmesan sauce.

How can I adjust the spice level?

Increase Cajun seasoning or chili flakes to boost heat, or reduce them for a milder flavor profile.

What can I use to lighten the sauce?

Substituting half-and-half for heavy cream will create a lighter sauce without sacrificing creaminess.

Spicy Cajun Chicken Alfredo

Tender Cajun-spiced chicken and fettuccine combine in a creamy Alfredo sauce with smoky paprika and garlic.

Prep Duration
15 minutes
Cook Duration
25 minutes
Overall Time
40 minutes
Created by Serena Moore


Skill Level Medium

Cuisine American

Makes 4 Portions

Dietary Details None specified

What You Need

Chicken

01 2 large boneless, skinless chicken breasts
02 2 tablespoons Cajun seasoning
03 1 tablespoon olive oil

Pasta

01 12 oz fettuccine

Alfredo Sauce

01 2 tablespoons unsalted butter
02 3 cloves garlic, minced
03 1 cup heavy cream
04 1 cup freshly grated Parmesan cheese
05 ½ teaspoon smoked paprika
06 ½ teaspoon chili flakes (optional)
07 Salt, to taste
08 Black pepper, to taste

Garnishes

01 2 tablespoons chopped fresh parsley
02 Extra grated Parmesan cheese

How To Make It

Step 01

Cook Pasta: Boil salted water and cook fettuccine until al dente according to package instructions. Reserve ½ cup pasta water, then drain and set aside.

Step 02

Prepare Chicken: Pat chicken breasts dry and coat evenly with Cajun seasoning.

Step 03

Cook Chicken: Heat olive oil in a large skillet over medium-high heat. Add chicken and cook 5 to 6 minutes per side until cooked through and golden brown. Remove and let rest 5 minutes, then slice thinly.

Step 04

Sauté Garlic: Reduce skillet heat to medium and melt butter. Sauté minced garlic for 1 minute until fragrant.

Step 05

Make Sauce: Stir in heavy cream, smoked paprika, and chili flakes. Bring to a gentle simmer, then whisk in Parmesan cheese until sauce is smooth. Season with salt and black pepper.

Step 06

Combine Pasta and Sauce: Add drained fettuccine to the sauce, tossing to coat completely. Add reserved pasta water gradually for desired sauce consistency.

Step 07

Assemble and Serve: Top pasta with sliced Cajun chicken. Garnish with chopped parsley and extra grated Parmesan. Serve immediately.

Tools You'll Need

  • Large pot
  • Large skillet
  • Tongs
  • Chef's knife
  • Cutting board
  • Measuring cups and spoons

Allergy Details

Review ingredients for allergens and speak to your healthcare provider if you have concerns.
  • Contains dairy (butter, cream, Parmesan)
  • Contains gluten (fettuccine)
  • Possible allergens in Cajun seasoning (check for mustard or celery)

Nutrition per Portion

Details are for reference and aren't a substitute for expert medical guidance.
  • Energy: 610
  • Lipids: 27 g
  • Carbohydrates: 54 g
  • Proteins: 38 g